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All records in the Specialised Register coded as ‘asthma’ were searched using the following terms:
(exacerbat* OR acute* or status* or severe* OR worsen* OR emergenc* OR attack* or crisis) and (dose* or dosing or dosage) and (doubl* or increas*) OR "dose response" or "drug dose") and (glucocorticoid* OR corticosteroid* OR "inhaled steroid*" OR fluticasone OR Flovent OR beclomethasone OR Becloforte OR budesonide OR Pulmicort OR flunisolide OR Aerobid OR triamcinolone OR Beclovent OR Azmacort OR Vanceril OR Becotide OR Flixotide OR Aerobec OR Mometasone OR Qvar or ciclesonide or Alvesco)
|
Database |
Frequency of search |
|
CENTRAL |
Monthly |
|
MEDLINE (Ovid) |
Weekly |
|
EMBASE (Ovid) |
Weekly |
|
PsycINFO (Ovid) |
Monthly |
|
CINAHL (EBSCO) |
Monthly |
|
AMED (EBSCO) |
Monthly |
|
Conference |
Years searched |
|
American Academy of Allergy, Asthma and Immunology (AAAAI) |
2001 onwards |
|
American Thoracic Society (ATS) |
2001 onwards |
|
Asia Pacific Society of Respirology (APSR) |
2004 onwards |
|
British Thoracic Society Winter Meeting (BTS) |
2000 onwards |
|
Chest Meeting |
2003 onwards |
|
European Respiratory Society (ERS) |
1992, 1994, 2000 onwards |
|
International Primary Care Respiratory Group Congress (IPCRG) |
2002 onwards |
|
Thoracic Society of Australia and New Zealand (TSANZ) |
1999 onwards |
1. exp Asthma/
2. asthma$.mp.
3. (antiasthma$ or anti-asthma$).mp.
4. Respiratory Sounds/
5. wheez$.mp.
6. Bronchial Spasm/
7. bronchospas$.mp.
8. (bronch$ adj3 spasm$).mp.
9. bronchoconstrict$.mp.
10. exp Bronchoconstriction/
11. (bronch$ adj3 constrict$).mp.
12. Bronchial Hyperreactivity/
13. Respiratory Hypersensitivity/
14. ((bronchial$ or respiratory or airway$ or lung$) adj3 (hypersensitiv$ or hyperreactiv$ or allerg$ or insufficiency)).mp.
15. ((dust or mite$) adj3 (allerg$ or hypersensitiv$)).mp.
16. or/1-15
1. exp "clinical trial [publication type]"/
2. (randomized or randomised).ab,ti.
3. placebo.ab,ti.
4. dt.fs.
5. randomly.ab,ti.
6. trial.ab,ti.
7. groups.ab,ti.
8. or/1-7
9. Animals/
10. Humans/
11. 9 not (9 and 10)
12. 8 not 11
The MEDLINE strategy and RCT filter are adapted to identify trials in other electronic databases.
#1 AST:MISC1
#2 MeSH DESCRIPTOR Asthma Explode All
#3 asthma*:ti,ab
#4 #1 or #2 or #3
#5 MeSH DESCRIPTOR Adrenal Cortex Hormones Explode All
#6 ICS:TI,AB
#7 (beclomethasone* or beclometasone* OR triamcinolone* OR fluticasone* OR budesonide* OR betamethasone* OR flunisolide* OR ciclesonide* OR mometasone*)
#8 (inhal*) NEAR5 (steroid* or corticosteroid* or glucocorticoid*)
#9 #5 or #6 or #7 or #8
#10 MeSH DESCRIPTOR Dose-Response Relationship, Drug
#11 (dose* or dosing or dosage) AND (doubl* or increas*)
#12 step-up* OR (step* NEXT up*)
#13 dose* NEXT reponse*
#14 drug* NEXT dose*
#15 #10 or #11 or #12 or #13 or #14
#16 MeSH DESCRIPTOR Disease Progression
#17 exacerbat* OR acute* or status* or severe* OR worsen* OR emergenc* OR attack* or crisis
#18 #16 or #17
#19 #4 AND #9 AND #15 AND #18
[Note: in search line #1, MISC1 denotes the field in the record where the reference has been coded for condition, in this case, asthma]
|
Source |
Terms and limits |
Hits |
|
Condition: Asthma exacerbation, date of registration from 1 March 2016 to present (any recruitment status, sponsor, location ). Condition: Asthma, Intervention: inhaled corticosteroids, date of registration from 1 March 2016 to present (any recruitment status, sponsor, location ). |
40
18 |
|
|
Terms: Asthma exacerbation, Phases 3 or 4, Therapeutic area: respiratory (any recruitment status, sponsor, location or product). |
14 |
|
|
Terms: asthma exacerbation, medical condition: asthma, Phases 3 or 4, study type: interventional (any recruitment status, phase, age, sex) |
99 |
|
|
Terms: asthma exacerbation |
20 |
|
|
Terms: asthma exacerbation |
4 |