Supplementary material 1 to: Focused review format prototype

Flemyng E, Mitchell D
https://doi.org/null

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Search strategies

Search strategy for the previous version of this review

All records in the Specialised Register coded as ‘asthma’ were searched using the following terms:

(exacerbat* OR acute* or status* or severe* OR worsen* OR emergenc* OR attack* or crisis) and (dose* or dosing or dosage) and (doubl* or increas*) OR "dose response" or "drug dose") and (glucocorticoid* OR corticosteroid* OR "inhaled steroid*" OR fluticasone OR Flovent OR beclomethasone OR Becloforte OR budesonide OR Pulmicort OR flunisolide OR Aerobid OR triamcinolone OR Beclovent OR Azmacort OR Vanceril OR Becotide OR Flixotide OR Aerobec OR Mometasone OR Qvar or ciclesonide or Alvesco)

Sources and search methods for the Cochrane Airways Group Specialised Register (CAGR)

Electronic searches: core databases

Database

Frequency of search

CENTRAL

Monthly

MEDLINE (Ovid)

Weekly

EMBASE (Ovid)

Weekly

PsycINFO (Ovid)

Monthly

CINAHL (EBSCO)

Monthly

AMED (EBSCO)

Monthly

Handsearches: core respiratory conference abstracts

Conference

Years searched

American Academy of Allergy, Asthma and Immunology (AAAAI)

2001 onwards

American Thoracic Society (ATS)

2001 onwards

Asia Pacific Society of Respirology (APSR)

2004 onwards

British Thoracic Society Winter Meeting (BTS)

2000 onwards

Chest Meeting

2003 onwards

European Respiratory Society (ERS)

1992, 1994, 2000 onwards

International Primary Care Respiratory Group Congress (IPCRG)

2002 onwards

Thoracic Society of Australia and New Zealand (TSANZ)

1999 onwards

MEDLINE search strategy used to identify trials for the CAGR

Asthma search

1. exp Asthma/

2. asthma$.mp.

3. (antiasthma$ or anti-asthma$).mp.

4. Respiratory Sounds/

5. wheez$.mp.

6. Bronchial Spasm/

7. bronchospas$.mp.

8. (bronch$ adj3 spasm$).mp.

9. bronchoconstrict$.mp.

10. exp Bronchoconstriction/

11. (bronch$ adj3 constrict$).mp.

12. Bronchial Hyperreactivity/

13. Respiratory Hypersensitivity/

14. ((bronchial$ or respiratory or airway$ or lung$) adj3 (hypersensitiv$ or hyperreactiv$ or allerg$ or insufficiency)).mp.

15. ((dust or mite$) adj3 (allerg$ or hypersensitiv$)).mp.

16. or/1-15

Filter to identify RCTs

1. exp "clinical trial [publication type]"/

2. (randomized or randomised).ab,ti.

3. placebo.ab,ti.

4. dt.fs.

5. randomly.ab,ti.

6. trial.ab,ti.

7. groups.ab,ti.

8. or/1-7

9. Animals/

10. Humans/

11. 9 not (9 and 10)

12. 8 not 11

The MEDLINE strategy and RCT filter are adapted to identify trials in other electronic databases.

Search strategy to identify relevant trials from the CAGR

#1 AST:MISC1

#2 MeSH DESCRIPTOR Asthma Explode All

#3 asthma*:ti,ab

#4 #1 or #2 or #3

#5 MeSH DESCRIPTOR Adrenal Cortex Hormones Explode All

#6 ICS:TI,AB

#7 (beclomethasone* or beclometasone* OR triamcinolone* OR fluticasone* OR budesonide* OR betamethasone* OR flunisolide* OR ciclesonide* OR mometasone*)

#8 (inhal*) NEAR5 (steroid* or corticosteroid* or glucocorticoid*)

#9 #5 or #6 or #7 or #8

#10 MeSH DESCRIPTOR Dose-Response Relationship, Drug

#11 (dose* or dosing or dosage) AND (doubl* or increas*)

#12 step-up* OR (step* NEXT up*)

#13 dose* NEXT reponse*

#14 drug* NEXT dose*

#15 #10 or #11 or #12 or #13 or #14

#16 MeSH DESCRIPTOR Disease Progression

#17 exacerbat* OR acute* or status* or severe* OR worsen* OR emergenc* OR attack* or crisis

#18 #16 or #17

#19 #4 AND #9 AND #15 AND #18

[Note: in search line #1, MISC1 denotes the field in the record where the reference has been coded for condition, in this case, asthma]

Additional searches (6 September 2021)

Source

Terms and limits

Hits

WHO International Clinical Trials Registry Platform

Condition: Asthma exacerbation, date of registration from 1 March 2016 to present (any recruitment status, sponsor, location ).

Condition: Asthma, Intervention: inhaled corticosteroids, date of registration from 1 March 2016 to present (any recruitment status, sponsor, location ).

40

18

AstraZeneca clinical trials

Terms: Asthma exacerbation, Phases 3 or 4, Therapeutic area: respiratory (any recruitment status, sponsor, location or product).

14

GlaxoSmithKline study register

Terms: asthma exacerbation, medical condition: asthma, Phases 3 or 4, study type: interventional (any recruitment status, phase, age, sex)

99

OpenGrey

Terms: asthma exacerbation

20

New York Academy of Medicine Grey Literature Report

Terms: asthma exacerbation

4