Supplementary material 3 to: Focused review format prototype

Flemyng E, Mitchell D
https://doi.org/null

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Characteristics of excluded studies

Table of contents

Studies ordered by Study ID

StudyReason for exclusion

Bateman 2008

Comparison of 2 doses of ciclesonide; not placebo controlled; uncontrolled asthma at baseline

Boushey 2005

Budesonide vs LTRA for mild persistent asthma

Brand 2011

ICS stopped during run-in, therefore no baseline ICS.

Bullard 1996

Systemic corticosteroids vs placebo for COPD, not asthma exacerbations

Clearie 2010

Stopped ICS for 2 weeks before trial. Not focused on exacerbations

Condemi 1999

Low- vs high-dose ICS; not placebo controlled; uncontrolled asthma at baseline

Connett 1993

No use of ICS at baseline

Currie 2003

Salmeterol-fluticasone vs fluticasone for uncontrolled asthma (not exacerbations)

De Benedictis 2005

Nebulised fluticasone vs budesonide; not placebo controlled; no use of ICS at baseline

Devidayal, 1999

Nebulised budesonide vs oral prednisone; not placebo controlled; no use of ICS at baseline

Farber 2016

Not an RCT; commentary

FitzGerald 2000

Use of systemic corticosteroids first; not placebo controlled

Gilbert 2018

Wrong design; commentary, not original RCT

GlaxoSmithKline 2005

Not placebo controlled; uncontrolled asthma at baseline

Greening 1994

BDP + salmeterol vs high-dose BDP; not placebo controlled; uncontrolled asthma at baseline

Hanania 2020

No short-term increase in ICS dose in response to an exacerbation

Hedlin 1999

Inhaled budesonide vs oral betamethasone; not placebo controlled

Heinig 1999

Budesonide vs fluticasone; not placebo controlled; uncontrolled asthma at baseline

Karpel 2007

Severe persistent asthma (not exacerbations); participants on OCS at baseline

La Rosa 1997

Salbutamol-flunisolide vs salbutamol; not placebo controlled

Lee-Wong 2002

Inhaled flunisolide vs systemic corticosteroids following IV corticosteroids; not placebo controlled

Lemanske 2010

3 step-up options and no stable study arm. ICS increased, but not in response to exacerbation.

Leuppi 2002

Unstable dose of ICS (dose reduction) before exacerbation

Levy 1996

Fluticasone vs oral prednisolone; not placebo controlled; not all participants on ICS at baseline

Manjra 2000

Nebulised fluticasone vs oral prednisolone; not placebo controlled; not all participants on ICS at baseline

Matz 2001

Salmeterol-fluticasone vs high-dose fluticasone for stable asthma (not exacerbations)

McKeever 2018

Study design; pragmatic, unblinded trial with no placebo control

Milani 2004

No use of ICS at baseline

Nana 1998

Inhaled budesonide vs oral prednisolone; not placebo controlled

NCT02995733

Participants not blinded to exacerbation strategy

Nuhoglu 2001

No use of ICS at baseline

O'Connor 2010

ICS given, but not in response to exacerbation.

Papi 2022

ICS given, but not in response to an exacerbation. All participants were on maintenance ICS, and the study included groups where the dose was kept stable or increased. However, the inhalers were used as a general rescue medication and preventative measure before exercise, not as part of an action plan to prevent exacerbations.

Pedersen 2009

ICS given, but not in response to exacerbation.

Prentice 2017

Wrong design; commentary on previous version of this review

Razi 2008

2 dosing regimens of nebulised budesonide; not placebo controlled

Rodrigo 1998

No use of ICS at baseline

Rodrigo 2005

Inhaled fluticasone vs IV hydrocortisone; no use of ICS at baseline

Schuh 2000

Inhaled fluticasone vs oral prednisolone; not all participants on ICS at baseline

Schuh 2006

Inhaled fluticasone vs oral prednisolone; not all participants on ICS at baseline

Sekerel 2005

Not all participants on ICS at baseline

Singhi 1999

Not all participants on ICS at baseline

Svedmyr 1995

ICS started at onset of URTI but not a confirmed asthma exacerbation; no ICS use at baseline

Volovitz 1998

Inhaled budesonide vs oral prednisone; not placebo controlled; no ICS use at baseline

Weinberger 2016

Wrong design; commentary on evidence, not primary study

Wilson 1990

Not all participants on ICS at baseline

Yousef 2012

No stable ICS arm

Footnotes

BDP: beclomethasone dipropionate
COPD: chronic obstructive pulmonary disease
ICS: inhaled corticosteroids
IV: intravenous
LTRA: leukotriene receptor agonists
OCS: oral corticosteroids
RCT: randomised controlled trial
URTI: upper respiratory tract infection

References to studies

Bateman 2008 {published data only}

Boushey 2005 {published data only}

Brand 2011 {published data only}

Bullard 1996 {published data only}

Clearie 2010 {published data only}

Condemi 1999 {published data only}

Connett 1993 {published data only}

Currie 2003 {published data only}

De Benedictis 2005 {published data only}

Devidayal, 1999 {published data only}

Farber 2016 {published data only}

FitzGerald 2000 {published data only}

Gilbert 2018 {published data only}

GlaxoSmithKline 2005 {published data only}

Greening 1994 {published data only}

Hanania 2020 {published data only}

Hedlin 1999 {published data only}

Heinig 1999 {published data only}

Karpel 2007 {published data only}

La Rosa 1997 {published data only}

Lee-Wong 2002 {published data only}

Lemanske 2010 {published data only}

Leuppi 2002 {published data only}

Levy 1996 {published data only}

Manjra 2000 {published data only}

Matz 2001 {published data only}

McKeever 2018 {published data only}

Milani 2004 {published data only}

Nana 1998 {published data only}

NCT02995733 {published data only}

Nuhoglu 2001 {published data only}

O'Connor 2010 {published data only}

Papi 2022 {published data only}

Pedersen 2009 {published data only}

Prentice 2017 {published data only}

Razi 2008 {published data only}

Rodrigo 1998 {published data only}

Rodrigo 2005 {published data only}

Schuh 2000 {published data only}

Schuh 2006 {published data only}

Sekerel 2005 {published data only}

Singhi 1999 {published data only}

Svedmyr 1995 {published data only}

Volovitz 1998 {published data only}

Weinberger 2016 {published data only}

Wilson 1990 {published data only}

Yousef 2012 {published data only}